REVIEW Trityl candesartan is a key intermediate used in the preparation of Candesartan, an angiotensin II receptor antagonist used mainly for the treatment of hypertension. Trityl candesartan is also used in the preparation of the prodrug candesartan cilexetil. Copper (II) complexex of trityl candesartan have also been shown to have antihypertensive activity.
REFERENCES
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Naka, Takehiko; Nishikawa, Kohei; Kato, Takeshi; Preparation of benzimidazole derivatives as angiotensin II antagonists Eur. Pat. Appl. (1991), EP 459136 A1 19911204.
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Etinger, Marina Yu; Fedotev, Boris; Preparation of candesartan cilexetil. PCT Int. Appl. (2005), WO 2005037821 A2 20050428.
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Soldevilla Madrid, Nuria; Process for preparation of candesartan cilexetil. PCT Int. Appl. (2007), WO 2007074399 A2 20070705.
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