139481-72-4 2-Ethoxy-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylic acid AKSci J90372
 
 
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  J90372    
2-Ethoxy-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylic acid
, 98%
 
Trityl candesartan




IDENTITY
CAS Number:139481-72-4
MDL Number:MFCD08436154
MF:C43H34N6O3
MW:682.77
SPECIFICATIONS & PROPERTIES
Purity:98%
Physical Form:White to off-white powder
Melting Point:163-175°C
Long-Term Storage:Store long-term at 2-8°C

REVIEW

 Trityl candesartan is a key intermediate used in the preparation of Candesartan, an angiotensin II receptor antagonist used mainly for the treatment of hypertension. Trityl candesartan is also used in the preparation of the prodrug candesartan cilexetil. Copper (II) complexex of trityl candesartan have also been shown to have antihypertensive activity.

REFERENCES
[1]Naka, Takehiko; Nishikawa, Kohei; Kato, Takeshi; Preparation of benzimidazole derivatives as angiotensin II antagonists Eur. Pat. Appl. (1991), EP 459136 A1 19911204.
[2] Etinger, Marina Yu; Fedotev, Boris; Preparation of candesartan cilexetil. PCT Int. Appl. (2005), WO 2005037821 A2 20050428.
[3] Soldevilla Madrid, Nuria; Process for preparation of candesartan cilexetil. PCT Int. Appl. (2007), WO 2007074399 A2 20070705.
[4] Hadizad, Tayebeh; Bioorganic & Medicinal Chemistry 2009, V17(23), P7971-7977

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of October 19, 2019


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For research use only. Not for diagnostic or therapeutic use.
Not for human use.


CATEGORIES

 APIs and Bioactives > Angiotensin Receptor Blockers


PubChem
  @PubMed