50-35-1 Thalidomide AKSci J90042
 
 
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  J90042    AKSci Bulk Reagent
Thalidomide, 95%
 
Thalomid
(+/-)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
IDENTITY
CAS Number:50-35-1
MDL Number:MFCD00153873
MF:C13H10N2O4
MW:258.23
EINECS:200-031-1
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:269-276°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III
A hazmat fee may apply depending on the amount ordered, as indicated in the list of package sizes.

BIOLOGICAL INFO
Solubility:DMSO: 52mg/mL; H2O: <1mg/mL; EtOH: 2mg/mL
Application(s):Angiogenesis Inhibitor; Immunosuppressive Agent; Leprostatic Agent; Teratogen
Form:Free Base

REVIEW
 Thalidomide is used for treating multiple myeloma in combination with dexamethasone, erythema nodosum leprosum, and alleviating symptoms of HIV, with strict controls to prevent birth defects. Thalidomide is a potent inhibitor of new blood vessel growth (angiogenesis), which is required for tumor growth.

REFERENCES
[1]Bejanyan N, Tiu RV, Raza A, Jankowska A, Kalaycio M, Advani A, Chan J, Saunthararajah Y, Mooney L, Maciejewski JP, Sekeres MA (2012). A phase 2 trial of combination therapy with thalidomide, arsenic trioxide, dexamethasone, and ascorbic acid (TADA) in patients with overlap myelodysplastic/myeloproliferative neoplasms (MDS/MPN) or primary myelofibrosis (PMF). Cancer. 118(16):3968-76. PMID 22180010.
[2] Horton MR, Hallowell RW (2012). Revisiting thalidomide: fighting with caution against idiopathic pulmonary fibrosis. Drugs Today (Barc). 48(10):661-71. PMID 23110262.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H301; H312; H361

Precautionary Statements
P201; P202; P264; P270; P280; P301+P310; P302+P352; P308+P313; P322; P330; P363; P405; P501

Current as of March 29, 2023


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⚠️
These chemical products are for research and development use only. They are not for diagnostic, therapeutic, cosmetic, or human and animal uses. They are not sold to individuals. Additional restrictions may apply.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information.
⚠️

WARNING: Attention California residents: This product can expose you to chemicals including Thalidomide, which is known to the State of California to cause birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov.




CATEGORIES
 APIs and Bioactives > Immunomodulators


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