61379-65-5 Rifapentine AKSci J90035
 
 
Loading Please Wait...
  J90035    
Rifapentine
, 90%
 
Cyclopentylrifampicin




IDENTITY
CAS Number:61379-65-5
MDL Number:MFCD00866806
MF:C47H64N4O12
MW:877.31
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:90%
Physical Form (at 20°C):Solid
Melting Point:179-180°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 100mg/mL; H2O: <1mg/mL; EtOH: 17mg/mL
Application(s):Antibiotic; Leprostatic Agent
Form:Free Base

REVIEW

 Rifapentine has shown higher bacteriostatic and bactericidal activities especially against intracellular bacteria growing in human monocyte-derived macrophages. Rifapentine inhibits DNA-dependent RNA polymerase in susceptible strains of M. tuberculosis. Rifapentine acts via the inhibition of DNA-dependent RNA polymerase, leading to a suppression of RNA synthesis and cell death.

REFERENCES
[1]Rosenthal IM, Zhang M, Williams KN et al. (December 2007). Daily Dosing of Rifapentine Cures Tuberculosis in Three Months or Less in the Murine Model. PLoS Medicine 4 (12): e344. doi:10.1371/journal.pmed.0040344. PMC 2140085. PMID 18092886.
[2] Dooley KE, Bliven-Sizemore EE, Weiner M, Lu Y, Nuermberger EL, Hubbard WC, Fuchs EJ, Melia MT, Burman WJ, Dorman SE (2012). Safety and pharmacokinetics of escalating daily doses of the antituberculosis drug rifapentine in healthy volunteers. Clin Pharmacol Ther. 91(5):881-8. PMID 22472995.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of October 9, 2024


Download SDS Request COA

All products are stocked and shipped from the SF Bay, California, USA via FedEx, UPS or DHL.
All batches backed with full quality assurance.
⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.



CATEGORIES

 APIs and Bioactives > Antibacterials, Rifamycins


PubChem