68291-97-4 Zonisamide AKSci J90034
 
 
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  J90034    
Zonisamide
, 95%
 
1,2-Benzisoxazole-3-methanesulfonamide
Zonegran
Exceglan
more..




IDENTITY
CAS Number:68291-97-4
MDL Number:MFCD00865316
MF:C8H8N2O3S
MW:212.23
SPECIFICATIONS & PROPERTIES
Purity:95%
Physical Form:White to light yellow crystalline powder
Melting Point:162-167°C
Long-Term Storage:Store long-term at 2-8°C

BIOLOGICAL INFO
Solubility:DMSO: 42mg/mL; H2O: <1mg/mL; EtOH: 5mg/mL
Application(s):Sodium and calcium channel blocker
Form:Free Base

REVIEW

 Zonisamide is a sulfonamide anticonvulsant approved for use as an adjunctive therapy in adults with partial-onset seizures; infantile spasm, mixed seizure types of Lennox-Gastaut syndrome, myoclonic, and generalized tonic clonic seizure.

REFERENCES
[1]Baulac M, Brodie MJ, Patten A, Segieth J, Giorgi L (2012). Efficacy and tolerability of zonisamide versus controlled-release carbamazepine for newly diagnosed partial epilepsy: a phase 3, randomised, double-blind, non-inferiority trial. Lancet Neurol. 11(7):579-88. PMID 22683226.
[2] McElroy SL, Winstanley E, Mori N, Martens B, McCoy J, Moeller D, Guerdjikova AI, Keck PE Jr (2012). A randomized, placebo-controlled study of zonisamide to prevent olanzapine-associated weight gain. J Clin Psychopharmacol. 32(2):165-72. PMID 22367654.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501


Current as of October 20, 2019


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For research use only. Not for diagnostic or therapeutic use.
Not for human use.


CATEGORIES

 APIs and Bioactives > Anticonvulsants


PubChem