82640-04-8 Raloxifene HCl AKSci J90021
 
 
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  J90021    
Raloxifene HCl
, 98%
 



IDENTITY
CAS Number:82640-04-8
MDL Number:MFCD01938233
MF:C28H28ClNO4S
MW:510.04
BRN:6036780
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98%
Physical Form (at 20°C):Solid
Melting Point:253-268°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 28mg/mL; H2O: <1mg/mL; EtOH: <1mg/mL
Application(s):Estrogen agonist/antagonist
Form:HCl salt

REVIEW

 An oral selective estrogen receptor modulator (SERM) that has estrogenic actions on bone and anti-estrogenic actions on the uterus and breast. It is used in the prevention of osteoporosis in postmenopausal women.

REFERENCES
[1]Hummel CW, Geiser AG, Bryant HU, Cohen IR, Dally RD, Fong KC, Frank SA, Hinklin R, Jones SA, Lewis G, McCann DJ, Rudmann DG, Shepherd TA, Tian H, Wallace OB, Wang M, Wang Y, Dodge JA (2005). A selective estrogen receptor modulator designed for the treatment of uterine leiomyoma with unique tissue specificity for uterus and ovaries in rats. J Med Chem. 48(22):6772-5. PMID 16250633.
[2] Yuan J, Johnson RL, Huang R, Wichterman J, Jiang H, Hayton K, Fidock DA, Wellems TE, Inglese J, Austin CP, Su XZ (2009). Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nat Chem Biol. 5(10):765-71. PMID 19734910.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of June 25, 2024


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CATEGORIES

 APIs and Bioactives > Estrogen Receptor Modulators


PubChem