63527-52-6 Cefotaxime AKSci J90010
 
 
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  J90010    
Cefotaxime
, 95%
 



IDENTITY
CAS Number:63527-52-6
MDL Number:MFCD00864971
MF:C16H17N5O7S2
MW:455.47
EINECS:264-299-1
SPECIFICATIONS & PROPERTIES
Purity:95%
Physical Form:White to off-white powder
Melting Point:>360°C
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Application(s):An antibiotic with broad spectrum activity against Gram positive and Gram negative bacteria

REVIEW

 Approximately 20-36% of an intravenously administered dose of 14C-cefotaxime is excreted by the kidney as unchanged cefotaxime and 15-25% as the desacetyl derivative, the major metabolite. The desacetyl metabolite has been shown to contribute to the bactericidal activity. Two other urinary metabolites (M2 and M3) account for about 20-25%. They lack bactericidal activity.

REFERENCES
[1]Petrova, M.V., et al. 2001. Anesteziol Reanimatol. 5: 58-60. PMID: 11757305
[2] Kern, W.V., et al. 1999. N. Engl. J. Med. 341:312-318. PMID: 10423465

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of October 19, 2019


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For research use only. Not for diagnostic or therapeutic use.
Not for human use.


CATEGORIES

 APIs and Bioactives > Antibacterials, Cephalosporins


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