91599-74-5 Benidipine hydrochloride AKSci J62876
 
 
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  J62876    
Benidipine hydrochloride, 95%
 
KW-3049
IDENTITY
CAS Number:91599-74-5
MDL Number:MFCD00906929
MF:C28H31N3O6.HCl
MW:542.23
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:209-215°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III
A hazmat fee may apply depending on the amount ordered, as indicated in the list of package sizes.

BIOLOGICAL INFO
Solubility:DMSO: =20 mg/mL
Application(s):Dihydropyridine calcium channel blocker
Form:HCl salt

REVIEW
 Benidipine hydrochloride is a single enantiomer dihydropyridine calcium channel blocker for the treatment of hypertension. It has also been shown to have anti-obesity activity. It inhibits not only L-type but also T-type calcium channels.

REFERENCES
[1]Muto, Kenji; Kuroda, Tokuyuki; Karasawa, Akira; Yamada, Koji; Nakamizo, Nobuhiro (±)-2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 1-benzyl-3-piperidyl methyl ester Eur. Pat. Appl. (1984), EP 106275 A2 19840425.
[2] Sano, Takahiro; Yamada, Yoshiyuki; Ogasa, Takehiro; Tamaoki, Kentaro 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 1-benzoyl-3-piperidinyl methyl ester diastereomers Jpn. Kokai Tokkyo Koho (1991), JP 03184974 A 19910812.
[3] Mori, Masahiko; Kawahara, Hiroshi; Kasai, Rie industrial preparation of high-purity benidipine hydrochloride Jpn. Tokkyo Koho (2006), JP 3763538 B2 20060405.
[4] Karasawa, Akira; Kubo, Kazuhiro Calcium antagonistic effects and the in vitro duration of actions of KW-3049, a new 1,4-dihydropyridine derivative, in isolated canine coronary arteries Japanese Journal of Pharmacology (1988), 47(1), 35-44.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H301

Precautionary Statements
P264; P270; P301+P310; P321; P330; P405; P501

Current as of December 9, 2023


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CATEGORIES
 APIs and Bioactives > Calcium Channel Blockers


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