REVIEW Stachydrine, a pyrrolidine betaine natural product was isolated from seed husk and the pulp of the fruit of Capparis tomentosa, the fruits of Capparis moonii and Leonurus sibiricus a number of other Asian plants and fruits. Leonurus sibiricus has been used in clinics to reduce postpartum hemorrhage with low toxicity and high efficiency as well as to promote blood circulation and dispel blood stasis. The major component of this traditional medicine is the stachydrine which was shown to induce the Th1/Th2/Th17/Treg paradigm which contributed to the reduction in uterine bleeding in RU486-induced abortion mice. Stachydrine has also been shown to be a potent anti-metastatic agent, which can markedly inhibit the malignancy and invasive capacity of malignant cancer cells.
REFERENCES
[1]
Cornforth, J. W.; Henry, Alan J. Isolation of L-stachydrine from the fruit of Capparis tomentosa. Journal of the Chemical Society (1952), 601-3.
[2]
Kanthamani, S.; Narayanan, C. R.; Venkataraman, K. Isolation of l-stachydrine and rutin from the fruits of Capparis moonii. Journal of Scientific & Industrial Research (1960), 19B, 409-10.
[3]
Yin J, Zhang ZW, Yu WJ, Liao JY, Luo XG, Shen YJ. Stachydrine, a major constituent of the Chinese herb leonurus heterophyllus sweet, ameliorates human umbilical vein endothelial cells injury induced by anoxia-reoxygenation. Am J Chin Med. 2010;38(1):157-71.
[4]
Li, Xia; Wang, Bin; Li, Yuzhu; Wang, Li; Zhao, Xiangzhong; Zhou, Xianbin; Guo, Yuqi; Jiang, Guosheng; Yao, Chengfang; The Th1/Th2/Th17/Treg paradigm induced by stachydrine hydrochloride reduces uterine bleeding in RU486-induced abortion mice. Journal of Ethnopharmacology (2013), 145(1), 241-253.
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