Loses 2'-O-butyryl group at pH 8.5. Impurity: =3% N6-monobutyryl-cyclic AMP; =0.5% cyclic AMP and 2'-O-monobutyryl-cyclic AMP
DOT/IATA TRANSPORT INFORMATION
Not hazardous material
BIOLOGICAL INFO
Solubility:
H2O:100mg/mL; DMSO (200mM) or 96% ethanol (25mM).
Application(s):
PKA activator; Phosphodiesterase inhibitor
Form:
Sodium salt
REVIEW Bucladesine is a cyclic nucleotide derivative, mimics the action of endogenous cAMP and is a phosphodiesterase inhibitor. A cell-permeable cAMP analog which preferentially activates cAMP-dependent protein kinase. The products releaes butyrate due to intracellular and extracellular esterase action. Butyrate was shown to have distinct biological effects. The compound is used in a wide variety of research applications because it mimics cAMP and can induce normal physiological responses when added to cells in experimental conditions.
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