120410-24-4 Biapenem AKSci J62046
 
 
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  J62046    
Biapenem
, 95%
 
L-627
LJC 10627
6-[[(4R,5S,6S)-2-Carboxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium inner salt




IDENTITY
CAS Number:120410-24-4
MDL Number:MFCD00864863
MF:C15H18N4O4S
MW:350.39
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:235-242°C
Optical Rotation:-32.9° (c=5)
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: <1mg/mL; H2O: 16mg/mL; EtOH: <1mg/mL
Application(s):Antibiotic
Form:Free Base

REVIEW

 A carbapenem antibiotic. It has in vitro activity against anaerobes.

REFERENCES
[1]Ikawa K, Nakashima A, Morikawa N, Ikeda K, Murakami Y, Ohge H, Derendorf H, Sueda T (2011). Clinical pharmacokinetics of meropenem and biapenem in bile and dosing considerations for biliary tract infections based on site-specific pharmacodynamic target attainment. Antimicrob Agents Chemother. 55(12):5609-15. PMID 21947393.
[2] Gatti DL (2012). Biapenem inactivation by B2 metallo β-lactamases: energy landscape of the post-hydrolysis reactions. PLoS One. 7(1):e30079. PMID 22272276.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of April 25, 2024


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CATEGORIES

 APIs and Bioactives > Antibacterials;Carbapenems


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