REVIEW Lacidipine is a dihydropyridine calcium channel blocker antagonist for the treatment of hypertension. It has a high membrane partition coefficient compared to other 1,4-dihydropyridine calcium-channel antagonists and a slow washout rate from membranes. Clinically, it also exhibits an extended duration of action.
REFERENCES
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Semeraro, Claudio; Micheli, Dino; Pieraccioli, Daniele; Gaviraghi, Giovanni; Borthwick, Allan David 4-Phenyl-1,4-dihydropyridinecarboxylic acid esters Ger. Offen. (1986), DE 3529997 A1 19860306.
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Pieraccioli, Daniele Esterification of (carboxyethenylphenyl)dihydropyridines using amide acetals Eur. Pat. Appl. (1990), EP 370974 A2 19900530.
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Sajja, Eswaraiah; Vetukuri, Venkata Naga Kali Vara Prasada Raju; Ningam, Srinivas Reddy; Vedantham, Ravindra Process for preparing lacidipine U.S. Pat. Appl. Publ. (2007), US 20070043088 A1 20070222.
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Micheli D, Ratti E, Toson G, Gaviraghi G. Pharmacology of lacidipine, a vascular-selective calcium antagonist. J Cardiovasc Pharmacol. 1991;17 Suppl 4:S1-8.
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