REVIEW Norethisterone enanthate is a synthetic oral progestin hormone with actions similar to those of progesterone but functioning as a more potent inhibitor of ovulation. It is used for contraception or to treat such conditions as secondary amenorrhea, abnormal uterine bleeding, and endometriosis. It is initially hydrolyzed by esterase, resulting in Norethisterone, which diffuses freely into target cells and bind to the progesterone receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary.
REFERENCES
[1]
Nishino, Y.; Neumann, F. Estrogenic partial effect of gestagens, in particular norethisterone enanthate. Arzneimittel-Forschung. (1980) 30(3): 439-52.
[2]
Benagiano, G.; Primiero, F. M. Norethindrone enanthate. Advances in Human Fertility and Reproductive Endocrinology. (1983) 2(Long-Acting Steroid Contracept.): 31-64.
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