136-47-0 Tetracaine HCl AKSci J61823
 
 
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  J61823    
Tetracaine HCl
, 95%
 
4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester hydrochloride




IDENTITY
CAS Number:136-47-0
MDL Number:MFCD00038912
MF:C15H25ClN2O2
MW:300.82
EINECS:205-248-5
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:130-149°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III
A hazmat fee may apply to certain package sizes. Please check pricing table for an indicator of applicable hazmat fees.

BIOLOGICAL INFO
Solubility:H2O: 50mg/mL
Application(s):Channel function allosteric inhibitor
Form:HCl salt

REVIEW

 A potent local anesthetic. Tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.

REFERENCES
[1]Liu Z, Shi Q, Ding D, Kelly R, Fang H, Tong W (2011). Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS Comput Biol. 7(12):e1002310. PMID 22194678.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H301; H317; H319

Precautionary Statements
P261; P264; P270; P272; P280; P301+P310; P302+P352; P305+P351+P338; P321; P330; P333+P313; P337+P313; P363; P405; P501


RELATED PRODUCTS
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Current as of April 26, 2024


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CATEGORIES

 APIs and Bioactives > Anaesthetics


PubChem