REVIEW Clodronate disodium is a first generation, non-nitrogen bisphosphonate. It inhibits the osteoclastic activity leading to bone resorption and osteoporosis. It is used as an anti-osteoporotic drug.
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Pohjala, Esko; Nupponen, Heikki; Lehmussaari, Kari Process for preparing a clodronate preparation PCT Int. Appl. (1995), WO 9513054 A1 19950518.
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Ljunghall S Use of clodronate and calcitonin in hypercalcemia due to malignancy. Recent Results Cancer Res. 1989;116:40-5.
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