2611-61-2 Thiamphenicol glycinate HCl AKSci J61592
 
 
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  J61592    
Thiamphenicol glycinate HCl, 95%
 
Neomyson G hydrochloride
TPG hydrochloride
Urfamicin hydrochloride
IDENTITY
CAS Number:2611-61-2
MDL Number:MFCD03093731
MF:C14H19Cl3N2O6S
MW:449.73
EINECS:220-033-6
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:184-185°C
Optical Rotation:+10.5° (H2O, 589.3nm)
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Form:HCl salt

REVIEW
 Thiamphenicol glycinate hydrochloride (also known as thiophenicol and dextrosulphenidol) is an antibiotic. It is the methyl-sulfonyl analogue of chloramphenicol and has a similar spectrum of activity, but is 2.5 to 5 times as potent. Like chloramphenicol, it is insoluble in water, but highly soluble in lipids. It is used in many countries as a veterinary antibiotic, but is available in China, Morocco and Italy for use in humans. Its main advantage over chloramphenicol is that it has never been associated with aplastic anaemia. Thiamphenicol is also widely used in Brazil, particularly for the treatment of sexually transmitted infections and pelvic inflammatory disease.

REFERENCES
[1]Portelli, Mario Preparation of D-(+)-threo- and DL-threo-1-(4-methylsulfonylphenyl)-2-dichloroacetamido-3-aminoacetoxy-1-propanol Annali di Chimica (Rome, Italy) (1964), 54(8-9), 816-20.
[2] Fontana, Angelo; Portelli, Mario; Schoffone, Ernesto Synthesis of chloramphenicol and thiamphenicol glycinates Gazzetta Chimica Italiana (1965), 95(11), 1385-96.
[3] Kawabe, Yasushi; Yamamoto, Noburo; Kanazawa, Tamotsu; Takimoto, Giichi; Miyamoto, Atsuko; Kanemasa, Yasuhiro; Okuma, Haruo Antibacterial effect of an antibiotic, thiophenicol Chemotherapy (Tokyo) (1966), 14(5), 421-6.
[4] Kanazawa, Tamotsu; Kawabe, Kiyoshi; Sato, Masaru; Fujita, Takeshi; Yamamoto, Shinro; Kanemasa, Yasuhiro Basic studies on thiamphenicol glycinate hydrochloride. II. Liberation from thiamphenicol glycinate hydrochloride to thiamphenicol Chemotherapy (Tokyo) (1970), 18(7), 937-40.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 19, 2024


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⚠️
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These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

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CATEGORIES
 APIs and Bioactives > Antibacterials


PubChem
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