L 700462, MK 383, N-(butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-L-tyrosine
IDENTITY
CAS Number:
150915-40-5
MDL Number:
MFCD07368623
MF:
C22H39ClN2O6S
MW:
495.07
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:
95%
Physical Form (at 20°C):
Solid
Melting Point:
88-98°C
Optical Rotation:
-10° - -18° (c=1, MeOH)
Long-Term Storage:
Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material
BIOLOGICAL INFO
Solubility:
DMSO: >12 mg/mL at warmed to 60 °C
REVIEW Tirofiban is a reversible antagonist of fibrinogen binding to the GP IIb/IIIa receptor, the major platelet surface receptor involved in platelet aggregation. Platelet aggregation inhibition is reversible following cessation of the infusion of tirofiban. Tirofiban hydrochloride monohydrate is a form of the compound being explored for use in an inhalative mode of administration.
REFERENCES
[1]
Li, Jianqi; Yin, Tao; Wang, Guan; Zhang, Feilong Process for preparation of tirofiban hydrochloride Faming Zhuanli Shenqing (2011), CN 102241622 A 20111116.
[2]
Hartman GD, Egbertson MS, Halczenko W, Laswell WL, Duggan ME, Smith RL, Naylor AM, Manno PD, Lynch RJ, Zhang G, Non-peptide fibrinogen receptor antagonists. 1. Discovery and design of exosite inhibitors. J Med Chem. 1992 Nov 27;35(24):4640-2.
[3]
Van Drie JH. Computer-aided drug design: the next 20 years. J Comput Aided Mol Des. 2007 Oct-Nov;21(10-11):591-601.
[4]
McClellan KJ, Goa KL. Tirofiban. A review of its use in acute coronary syndromes. Drugs. 1998 Dec;56(6):1067-80.
All products are stocked and shipped from the SF Bay, California, USA via FedEx, UPS or DHL.
All batches backed with full quality assurance.
⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.
These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.
Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.
New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.
Add to Favorites 
Delete from Favorites 
