113852-37-2 Cidofovir, anhydrous AKSci J57598
 
 
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  J57598    
Cidofovir, anhydrous, 95%
 



IDENTITY
CAS Number:113852-37-2
MDL Number:MFCD00866936
MF:C8H14N3O6P
MW:279.19
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:260°C
Optical Rotation:-97.3° (c=0.80, in H2O)
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III
A hazmat fee may apply to certain package sizes and shipment methods. Please check pricing table for an indicator of applicable hazmat fees.

BIOLOGICAL INFO
Form:Free base
Research Area:Infection

REVIEW
 Cidofovir is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA polymerase. It is an acyclic nucleoside phosphonate, and is therefore independent of phosphorylation by viral enzymes. Cidofovir has shown efficacy against HSV, VZV, CMV, and acyclovir-resistant herpes.

REFERENCES
[1]Holy, Antonin; Rosenberg, Ivan; De Clercq, Erik Preparation and testing of N-phosphonylmethoxyalkyl derivatives of pyrimidine and purine bases with antiviral activity Eur. Pat. Appl. (1988), EP 253412 A2 19880120.
[2] Petr, Alexander; Antonin, Holy; Dvorakova, Hana Preparation of acyclonucleoside phosphonates as antiviral agents Eur. Pat. Appl. (1992), EP 470809 A1 19920212.
[3] Bronson, Joanne J.; Ghazzouli, Ismail; Hitchcock, Michael J. M.; Webb, Robert R., II; Martin, John C. Synthesis and antiviral activity of the nucleotide analog (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cystosine Journal of Medicinal Chemistry (1989), 32(7), 1457-63.
[4] De Clercq E.Therapeutic potential of phosphonylmethoxyalkylpurines and -pyrimidines as antiviral agents.Drugs Exp Clin Res. 1990;16(7):319-26.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302; H315; H319; H335

Precautionary Statements
P261; P264; P270; P271; P280; P301+P312; P302+P352; P304+P340; P305+P351+P338; P312; P321; P330; P332+P313; P337+P313; P362; P403+P233; P405; P501

RELATED PRODUCTS
G721Cidofovir, anhydrous
Y0283Cidofovir hydrate

Current as of October 15, 2024


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CATEGORIES
 APIs and Bioactives > Antivirals


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