REVIEW Nafamostat mesylate is a highly effective tryptase (Ki=95.3 pM) inhibitor. The compound has the ability to promote synthesis of interferon-gamma, tumor necrosis factor-alpha, IL-12, and IL-18. Additionally, Nafamostat mesylate can induce production of intercellular adhesion molecules-1, B7.1, B7.2, CD40 and CD40 ligand in human blood mononuclear cells. Nafamostat mesylate is an anticoagulant and has been shown to decrease levels of plasma myeloperoxidase, and has also been used in ERCP pancreatitis studies. Nafamostat mesylate is an inhibitor of Factor X, Factor XII, granzyme A and KLK.
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