912-60-7 Noscapine hydrochloride hydrate AKSci J55710
 
 
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  J55710    
Noscapine hydrochloride hydrate, 98%
 
Noscapine hydrochloride
IDENTITY
CAS Number:912-60-7
MDL Number:MFCD00149223
MF:C22H23NO7·HCl·xH2O
MW:449.89 (anhy)
EINECS:213-014-9
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98%
Physical Form (at 20°C):Solid
Melting Point:221-223°C
Optical Rotation:+43.0 to +47.0° (C=0.5, 0.1mol/L HCl)(calcd.on anh.substance)
Refractive Index:1.6
Long-Term Storage:Store long-term at 2-8°C
Note:Water: 2.0 to 6.0 %
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:Soluble in water, and 1eq. HCl (50 mM)
Application(s):A bradykinin B and tubulin inhibitor

REVIEW
 Noscapine hydrochloride is the hydrochloride form of Noscapine. Noscapine is an opioid alkaloid with several actions. Antagonist at Bradykinin B Receptor (bradykinin receptors) (pA2 = 6.68), inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated cAMP increases in CNS tissues. Additionally Noscapine binds to tubulin, arrests cells in mitosis and induces apoptosis. Blocks proliferation of human leukemia and multiple myeloma cells. Furthermore, Noscapine modulates IKK activation, suppressing the NF-κB signaling pathway. Exhibits anti-inflammatory activity. Noscapine hydrochloride is an inhibitor of Tubulin. IC50 data: CYP2C19: IC50 = 400.3 nM (human); HepG2: IC50 >1000 nM (human); A549: EC5050 = 25 μM (human)

REFERENCES
[1]Mourey, R.J., et al. 1992. Mol. Pharmacol. 42: 619-626.
[2] Ye, K., et al. 1998. Proc. Natl. Acad. Sci. U.S.A. 95: 1601-1606.
[3] Mahmoudian, M. and Mojaverian, M. 2001. Acta Physiol. Hung. 88: 231-237.
[4] Landen, J.W., et al. 2002. Cancer Res. 62: 4109-4114.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312+P330; P501

RELATED PRODUCTS
8941AJNoscapine base

Current as of April 20, 2024


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CATEGORIES
 APIs and Bioactives > Alkaloids


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