67392-87-4 Drospirenone AKSci J55516
 
 
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  J55516    
Drospirenone, 95%
 
6beta,7beta,15beta,16beta -Dimethylene-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone, Dihydrospirorenone
Angeliq
IDENTITY
CAS Number:67392-87-4
MDL Number:MFCD00867350
MF:C24H30O3
MW:366.49
EINECS:266-679-2
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:196-200°C
Optical Rotation:-180° - -195° (c=1, MeOH)
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 73mg/mL; H2O: <1mg/mL; EtOH: 11mg/mL
Application(s):Progestogen Receptor
Form:Free Base

REVIEW
 Extensively metabolized following oral or intravenous administration. The two major metabolites are inactive and are formed independent of the CYP450 enzyme system. The metabolites are the acid form of drospirenone formed by opening of the lactone ring and the 4,5-dihydro-drospirenone-3-sulfate.

REFERENCES
[1]Westhoff C, Kaunitz AM, Korver T, Sommer W, Bahamondes L, Darney P, Verhoeven C (2012). Efficacy, safety, and tolerability of a monophasic oral contraceptive containing nomegestrol acetate and 17beta-estradiol: a randomized controlled trial. Obstet Gynecol. 119(5):989-99. PMID 22525910.
[2] Anzai Y, Heger-Mahn D, Schellschmidt I, Marr J (2012). Suppression of ovarian activity with a low-dose 21/7-day regimen oral contraceptive containing ethinylestradiol 20 mcg/drospirenone 3 mg in Japanese and Caucasian women. Contraception. 86(1):28-34. PMID 22402257.
[3] Krattenmacher R: Drospirenone: pharmacology and pharmacokinetics of a unique progestogen. Contraception. 2000 Jul;62(1):29-38.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H360

Precautionary Statements
P201; P202; P281; P308+P313; P405; P501

Current as of April 19, 2024


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CATEGORIES
 APIs and Bioactives > Steroid Hormones


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