518-34-3 Tetrandrine AKSci J54872
 
 
Loading Please Wait...
  J54872    
Tetrandrine
, 95%
 



IDENTITY
CAS Number:518-34-3
MDL Number:MFCD08689909
MF:C38H42N2O6
MW:622.75
SPECIFICATIONS & PROPERTIES
Purity:95%
Physical Form:White powder
Melting Point:219-222°C
Optical Rotation:+285° (c=1, CHCl3)
Long-Term Storage:Store long-term at room temperature

BIOLOGICAL INFO
Application(s):Calcium channel blocker
Form:Free Base
Research Area:Cancer

REVIEW

 Tetrandrine a bis-benzylisoquinoline alkaloid, a principle from a traditional Chinese medicine of the root of Stephania tetrandra S Moore, and other Chinese and Japanese herbs,and is a calcium channel blocker with a wide range of biological effects. Tetrandrine demonstrates antiinflammatory, antifibrogenetic, immunomodulating and antioxidant effects, it also presents antiallergic effects, inhibitory effects on pulmonary vessels and airway smooth muscle contraction, and platelet aggregation via its nonspecific calcium channel antagonism that suggested its potential in the treatment of asthma, pulmonary hypertension and chronic obstructive pulmonary disease.

REFERENCES
[1]Chen Y, Tsai YH, Tseng SH. The potential of tetrandrine as a protective agent for ischemic stroke. Molecules. 2011 Sep 16;16(9):8020-32.
[2] Chen Y, Tseng SH. The Potential of Tetrandrine against Gliomas. Anticancer Agents Med Chem. 2010 Sep;10(7):534-42.
[3] Wang G, Lemos JR, Iadecola C. Herbal alkaloid tetrandrine: from an ion channel blocker to inhibitor of tumor proliferation. Trends Pharmacol Sci. 2004 Mar;25(3):120-3.
[4] Xie QM, Tang HF, Chen JQ, Bian RL, Pharmacological actions of tetrandrine in inflammatory pulmonary diseases. Acta Pharmacol Sin. 2002 Dec;23(12):1107-13.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of July 11, 2020


Download SDS

For research use only. Not for diagnostic or therapeutic use. Not for human use. AK Scientific, Inc. does not sell to individuals. If you are a first-time customer, please email for review at least two official business documents issued by your local jurisdiction, state/province, or country.


CATEGORIES

 APIs and Bioactives > Calcium channel blockers, Alkaloids


PubChem
  @PubMed