14222-60-7 2-propylpyridine-4-carbothioamide AKSci J54498
 
 
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  J54498    AKSci Bulk Reagent
2-propylpyridine-4-carbothioamide, 95%
 
2-Propyl-thioisonicotinamide
IDENTITY
CAS Number:14222-60-7
MDL Number:MFCD00464119
MF:C9H12N2S
MW:180.27
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:140-146°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW
 Protionamide (also known as prothionamide) is used in the treatment of tuberculosis and leprosy. Protionamide mode of action involves bioactivation via flavin monoxygenase, which then form covalent adducts with nicotinamide adenine dinucleotide (NAD) with protinamide, and that these adducts are tight-binding inhibitors of M. tuberculosis and M. leprae enoyl CoA reductase InhA, the ultimate target of these. The crystal structures of the inhibited M. leprae and M. tuberculosis InhA complexes provide the molecular details of target-drug interactions. The purified ETH-NAD and PTH-NAD adducts both showed nanomolar Kis against M. tuberculosis and M. leprae InhA.

REFERENCES
[1]Wang F, Langley R, Gulten G, Dover LG, Besra GS, Jacobs WR Jr, Sacchettini JC. Mechanism of thioamide drug action against tuberculosis and leprosy. J Exp Med. 2007 Jan 22;204(1):73-8. Epub 2007 Jan 16.
[2] Fajardo TT, Guinto RS, Cellona RV, Abalos RM, Dela Cruz EC, Gelber RH. A clinical trial of ethionamide and prothionamide for treatment of lepromatous leprosy. Am J Trop Med Hyg. 2006 Mar;74(3):457-61.
[3] Prothionamide. Tuberculosis (Edinb). 2008 Mar;88(2):139-40.
[4] Grosset, J. Antibacterial treatment of leprosy Edited by Bryskier, Andre , Antimicrobial Agents (2005), 1168-1178.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of November 21, 2024


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All batches backed with full quality assurance.
⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

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CATEGORIES
 APIs and Bioactives > Antibacterials


PubChem
  @PubMed