131707-23-8 Arbidol HCl AKSci J54404
 
 
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  J54404    
Arbidol HCl, 95%
 



IDENTITY
CAS Number:131707-23-8
MDL Number:MFCD00344795
MF:C22H26BrClN2O3S
MW:513.88
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:141-143°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Form:HCl salt

REVIEW
 Arbidol is an antiviral treatment for influenza infection. It inhibits membrane fusion, preventing contact between the virus and target host cells. Evidence suggests that its actions are more effective at preventing infections from RNA viruses than infections from DNA viruses. As well as specific antiviral action against both influenza A and influenza B viruses, arbidol exhibits modulatory effects on the immune system. It stimulates a humoral immune response, induces interferon production, and stimulates the phagocytic function of macrophages.

REFERENCES
[1]Grinev, A. N.; Pershin, G. N Preparation of ethyl 6-bromo-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-phenylthiomethyl-3-indolecarboxylate hydrochloride monohydrate as a virucide, immunostimulant, and interferon-inducing agent PCT Int. Appl. (1990), WO 9008135 A1 19900726.
[2] Wang, Dun; Wu, Xiujing; Gong, Ping Synthesis of Arbidol Hydrochloride Zhongguo Yiyao Gongye Zazhi (2004), 35(8), 457-458.
[3] Chai Huifang; Zhao Yanfang; Zhao Chunshen; Gong Ping Synthesis and in vitro anti-hepatitis B virus activities of some ethyl 6-bromo-5-hydroxy-1H-indole-3-carboxylates Bioorganic & medicinal chemistry (2006), 14(4), 911-7.
[4] Cao, Zhifei; Dong, Jun; Shi, Lin Process for preparation of arbidol hydrochloride from 3-iodo-4-nitrophenol Faming Zhuanli Shenqing (2012), CN 102351778 A 20120215.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319

Precautionary Statements
P264; P280; P302+P352; P305+P351+P338; P321; P332+P313; P337+P313; P362

Current as of October 15, 2024


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CATEGORIES
 APIs and Bioactives > Antivirals;Influenza


PubChem
  @PubMed