6533-68-2 Scopolamine hydrobromide trihydrate AKSci J54180
 
 
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  J54180    
Scopolamine hydrobromide trihydrate, 95%
 
Hyoscine hydrobromide
Scopine tropate
IDENTITY
CAS Number:6533-68-2
MDL Number:MFCD00150066
MF:C17H21NO4.BrH.3H2O
MW:438.31
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:84-87°C
Optical Rotation:-22 - -26° (c=5, H2O)
Long-Term Storage:Store long-term in a cool, dry place
Note:195-199°C (dry matter)
DOT/IATA TRANSPORT INFORMATION
UN #:UN1544
Hazard Class:6.1; Poison
Packing Group:III
A hazmat fee may apply depending on the amount ordered, as indicated in the list of package sizes.

BIOLOGICAL INFO
Solubility:H2O: 50mg/mL
Application(s):Competitive nonselective muscarinic acetylcholine antagonist
Form:Hydrate

REVIEW
 Scopolamine hydrobromide trihydrate is an alkaloid from Solanaceae. It is used for the treatment of excessive salivation, colicky abdominal pain, bradycardia, sialorrhoea, diverticulitis, irritable bowel syndrome and motion sickness. Scopolamine is a muscarinic antagonist structurally similar to the neurotransmitter acetylcholine and acts by blocking the muscarinic acetylcholine receptors and is thus classified as an anticholinergic.

REFERENCES
[1]Safer D J; Allen R P. The central effects of scopolamine in man. Biological psychiatry. (1971) 3(4): 347-55.
[2] Kanto J; Klotz U. Pharmacokinetic implications for the clinical use of atropine, scopolamine and glycopyrrolate. Acta anaesthesiologica Scandinavica. (1988) 32(2): 69-78.
[3] Sandlin Debbie. Transderm scopolamine: a painless, noninvasive option for control of postoperative nausea and vomiting. Journal of Perianesthesia Nursing : official journal of the American Society of PeriAnesthesia Nurses / American Society of PeriAnesthesia Nurses. (2002) 17(6): 427-9.
[4] Subroto, M. Ahkam; Kwok, Kian H.; Hamill, John D.; Doran, Pauline M.Coculture of genetically transformed roots and shoots for synthesis, translocation, and biotransformation of secondary metabolites Biotechnology and Bioengineering (1996), 49(5), 481-94

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H301; H310+H330

Precautionary Statements
P260; P262; P264; P270; P271; P280; P284; P301+P310; P302+P350; P304+P340; P310; P320; P330; P361; P363; P403+P233; P405; P501

RELATED PRODUCTS
R028(-)-Scopolamine N-butyl bromide
X4633Scopolamine hydrobromide trihydrate

Current as of June 9, 2023


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