2277-92-1 Oxyclozanide AKSci J53944
 
 
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  J53944    
Oxyclozanide, 95%
 
2,3,5-Trichloro-N-(3,5-dichloro-2-hydroxyphenyl)-6-hydroxybenzamide
3,3',5,5',6-Pentachloro-2'-hydroxysalicylanilide
IDENTITY
CAS Number:2277-92-1
MDL Number:MFCD00864507
MF:C13H6Cl5NO3
MW:401.46
EINECS:218-904-0
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:209-211°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW
 Oxyclozanide is a salicylanilide anthelmintic. It is used in veterinary medicine in the treatment and control of Fascioliasis in ruminants, mainly cattle, sheep and goats. Oxyclozanide, an example of a proton ionophore, uncouples oxidative phosphorylation of the target organism.

REFERENCES
[1]Walley JK. Oxyclozanide (3,3',5,5',6-pentachloro-2,2'-dihydroxybenzanilide--6Zanil'') in the treatment of the liver fluke Fasciola hepatica in sheep and cattle. Vet Rec. 1966 Feb 19;78(8):267-76.
[2] Coles GC, Stafford KA. Vet Rec. Activity of oxyclozanide, nitroxynil, clorsulon and albendazole against adult triclabendazole-resistant Fasciola hepatica. 2001 Jun 9;148(23):723-4.
[3] Iglesias R, Paramá A, Alvarez MF, Leiro J, Sanmartín ML. Antiprotozoals effective in vitro against the scuticociliate fish pathogen Philasterides dicentrarchi. Dis Aquat Organ. 2002 Jun 3;49(3):191-7.
[4] Paraud C, Gaudin C, Pors I, Chartier C. Efficacy of oxyclozanide against the rumen fluke Calicophoron daubneyi in experimentally infected goats. Vet J. 2009 May;180(2):265-7.
[5] Martin RJ.Modes of action of anthelmintic drugs. Vet J. 1997 Jul;154(1):11-34.
[6] Swan GE.The pharmacology of halogenated salicylanilides and their anthelmintic use in animals. J S Afr Vet Assoc. 1999 Jun;70(2):61-70.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302; H410

Precautionary Statements
P264; P270; P273; P301+P312; P330; P391; P501

Current as of April 20, 2024


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⚠️
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CATEGORIES
 APIs and Bioactives > Antiparasitics


PubChem
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