REVIEW Pazufloxacin mesylate is a fused tricyclic fluoroquinoline antibacterial salt with a 1-aminocyclopropyl substituent at C10 position. The presence of an aminoacyl group at C10 is a unique feature of the molecule, imparting potent broad spectrum activity against gram-positive and gram-negative bacteria including a variety of resistant strains and anaerobic bacteria. Pazufloxacin has shown multimodal mechanism of action and inhibits both DNA gyrase and topoisomerase IV enzyme, leading to increased antibacterial spectrum via DNA gyrase-dependent processes such as DNA polymerization, (ATP-dependent) DNA supercoiling, and chromosome fragmentation. Moreover, pazufloxacin has been shown to have DNA antagonistic actions too. The multimodal mechanism of action is linked to the low potential for the development of resistance in pazufloxacin. Moreover, it has been shown that pazufloxacin is not affected by efflux mechanism of resistance.
REFERENCES
[1]
Narita, Hirokazu; Todo, Yozo; Nitta, Jun; Takagi, Hiroyasu; Iino, Fumihiko; Miyajima, Mikako; Fukuoka, Yoshikazu; Saikawa, Isamu Preparation, testing, and formulation of oxopyridobenzoxazinecarboxylates, -benzothiazinecarboxylates, and -quinoxalinecarboxylates as antibacterials Ger. Offen. (1989), DE 3913245 A1 19891102.
Todo, Yozo; Takagi, Hiroyasu; Iino, Fumihiko; Fukuoka, Yoshikazu; Takahata, Masahiro; Okamoto, Seiki; Saikawa, Isamu; Narita, Hirokazu Pyridonecarboxylic acids as antibacterial agents. IX. Synthesis and structure-activity relationship of 3-substituted 10-(1-aminocyclopropyl)-9-fluoro-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acids and their 1-thio and 1-aza analogs. Chemical & Pharmaceutical Bulletin (1994), 42(12), 2569-74.
[4]
Todo, Yozo; Takagi, Hiroyasu; Iino, Fumihiko; Hayashi, Kazuya; Takata, Makoto; Kuroda, Hiroshi; Momonoi, Kaishu; Narita, Hirokazu Practical synthesis of T-3761, (S)-10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid Chemical & Pharmaceutical Bulletin (1994), 42(12), 2629-32.
All products are stocked and shipped from San Francisco Bay Area, California, USA.
⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.
These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.
Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.
New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.
Add to Favorites 
Delete from Favorites 
