REVIEW Benzbromarone is a uricosuric agent and non-competitive inhibitor of xanthine oxidase used in the treatment of gout, especially when allopurinol, a first-line treatment, fails or produces intolerable adverse effects. It is highly effective and well tolerated, and clinical trials as early as 1981. In 2003, the drug was withdrawn after reports of serious hepatotoxicity, although it is still marketed in several countries by other drug companies.
REFERENCES
[1]
Heel, R. C.; Brogden, R. N.; Speight, T. M.; Avery, G. S. Benzbromarone: a review of its pharmacological properties and therapeutic use in gout and hyperuricemia. Drugs. (1977) 14(5): 349-66.
[2]
Lee, Ming-Han H.; Graham, Garry G.; Williams, Kenneth M.; Day, Richard O. A benefit-risk assessment of benzbromarone in the treatment of gout: was its withdrawal from the market in the best interest of patients? Drug Safety. (2008) 31(8): 643-665.
[3]
Perez-Ruiz, Fernando; Hernando, Inaki; Herrero-Beites, Ana M. Uricosuric therapy Edited by Wortmann, Robert L. Crystal-Induced Arthropathies. (2006): 369-380.
[4]
Buu-Hoi, Nguyen Ph.; Beaudet, Camille Benzofurans (1961), US 3012042 19611205.
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