7481-89-2 2',3'-Dideoxycytidine AKSci J52799
 
 
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  J52799    
2',3'-Dideoxycytidine, 95%
 
Zalcitabine
Hivid
Dideoxycytidine
IDENTITY
CAS Number:7481-89-2
MDL Number:MFCD00012188
MF:C9H13N3O3
MW:211.22
BRN:654956
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:214-219°C
Optical Rotation:90° (c=0.5,in H2O)
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 42mg/mL; H2O: 42mg/mL; EtOH: <1mg/mL
Application(s):Nucleoside analog HIV reverse transcriptase inhibitor (NARTI)
Form:Free Base

REVIEW
 Zalcitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Within cells, zalcitabine is converted to its active metabolite, dideoxycytidine 5'-triphosphate (ddCTP), by the sequential action of cellular enzymes. ddCTP interferes with viral RNA-directed DNA polymerase (reverse transcriptase) by competing for utilization of the natural substrate deoxycytidine 5'-triphosphate (dCTP), as well as incorpating into viral DNA. Due to it's lack of a 3'-OH group, the formation of a 5' to 3' phosphodiester linkage that is necessary for DNA chain elongation is inhibited, thus leading to the termination of viral DNA growth.

REFERENCES
[1]Shelton MJ, O'Donnell AM, Morse GD: Zalcitabine. Ann Pharmacother. 1993 Apr;27(4):480-9.
[2] Devineni D, Gallo JM: Zalcitabine. Clinical pharmacokinetics and efficacy. Clin Pharmacokinet. 1995 May;28(5):351-60.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H351

Precautionary Statements
P201; P202; P281; P308+P313; P405; P501

Current as of November 21, 2024


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All products are stocked and shipped from the SF Bay, California, USA via FedEx, UPS or DHL.
All batches backed with full quality assurance.
⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.
⚠️

WARNING: Attention California residents: This product can expose you to chemicals including 2',3'-Dideoxycytidine, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.




CATEGORIES
 APIs and Bioactives > Antivirals, Antiretrovirals, NRTIs
 Nucleobases > Nucleosides
 Nucleobases > Nucleosides


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