100361-18-0 1-Cyclopropyl-6-fluoro-7-chloride-4-oxo-1,4-dihydro-1,8-napthyridine-3-carboxylic acid AKSci J52683
 
 
Loading Please Wait...
  J52683    AKSci Bulk Reagent
1-Cyclopropyl-6-fluoro-7-chloride-4-oxo-1,4-dihydro-1,8-napthyridine-3-carboxylic acid
, 98%
 



IDENTITY
CAS Number:100361-18-0
MDL Number:MFCD08458865
MF:C12H8ClFN2O3
MW:282.65
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98%
Physical Form (at 20°C):Solid
Melting Point:222-226°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW

 1-Cyclopropyl-6-fluoro-7-chloride-4-oxo-1,4-dihydro-1,8-napthyridine-3-carboxylic acid is a key intermediate in the synthesis of 7-amine based fluoroquinoline antibacterials agents. Reaction at the 7- chloro with amines, in particular secondary amines, gives rise to a range of fluoroquinolones with antibacterial activity.

REFERENCES
[1]Mich, Thomas F.; Sanchez, Joseph P.; Domagala, John M.; Trehen, Ashok K. 1-Cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids; 1-cyclopropyl-1, 4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acids and their derivatives Eur. Pat. Appl. (1985), EP 153828 A2 19850904.
[2] Hayakawa, Isao 1,8-Naphthyridine derivatives Jpn. Kokai Tokkyo Koho (1985), JP 60172981 A 19850906.
[3] Mich, Thomas F.; Sanchez, Joseph P.; Domagala, John M. Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acids; substituted-5-amino-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids; their derivatives; and pharmaceutical compositions compris Eur. Pat. Appl. (1986), EP 172651 A1 19860226.
[4] Sanchez, Joseph P.; Domagala, John M.; Hagen, Susan E.; Heifetz, Carl L.; Hutt, Marland P.; Nichols, Jeffry B.; Trehan, Ashok K. Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids Journal of Medicinal Chemistry (1988), 31(5), 983-91.
[5] Nishimura, Yoshiro; Hirose, Tohru; Okada, Hidetsugu; Shibamori, Kohichiro; Nakano, Junji; Matsumoto, Junichi Pyridonecarboxylic acid antibacterial agents. XV. Synthesis of 7-thio-substituted 4-oxoquinoline-3-carboxylic acids with antibacterial activity Chemical & Pharmaceutical Bulletin (1990), 38(8), 2190-6.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of October 16, 2024


Download SDS Request COA

All products are stocked and shipped from the SF Bay, California, USA via FedEx, UPS or DHL.
All batches backed with full quality assurance.
⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.



CATEGORIES

 APIs and Bioactives > Antibacterials, Quinolones


PubChem