REVIEW Vinblastine is an antimicrotubule drug used to treat certain cancers. Vinblastine was traditionally obtained from the periwinkle plant Vinca rosea, in which it is biosynthesized by the joining of two alkaloids, catharanthine and vindoline. Vinblastine binds to tubulin and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and arrest of tumor cells in the M phase of the cell cycle.
REFERENCES
[1]
Kuehne, M. E.; Matson, P. A.; Bornmann, W. G. Enantioselective Syntheses of Vinblastine, Leurosidine, Vincovaline, and 20'-epi-Vincovaline, Journal of Organic Chemistry 1991,56 (2): 513-528.
[2]
Yokoshima, S; Tokuyama, H; Fukuyama, T. Total Synthesis of (+)-Vinblastine: Control of the Stereochemistry at C18' . The Chemical Record 2009, 10 (2): 101-118.
[3]
Houghton PJ, Houghton JA, Bowman LC, Hazelton BJ.Therapeutic selectivity of vinca alkaloids: a role for guanosine 5'-triphosphate Anticancer Drug Des. 1987 Oct;2(2):165-79.
[4]
Navarro M, Bellmunt J, Balañá C, Colomer R, Jolis L, del Campo JM Mitomycin-C and vinblastine in advanced breast cancer. Oncology. 1989;46(3):137-42.
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