965-52-6 5-Nitro-2-furaldehyde p-hydroxybenzoylhydrazone AKSci J51953
 
 
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  J51953    AKSci Bulk Reagent
5-Nitro-2-furaldehyde p-hydroxybenzoylhydrazone
, 95%
 
Nifuroxazide




IDENTITY
CAS Number:965-52-6
MDL Number:MFCD00079482
MF:C12H9N3O5
MW:275.22
EINECS:213-522-0
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:298°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW

 Nifuroxazide is an oral nitrofuran antibiotic (1966) and used worldwide to treat colitis and diarrhea in humans and non-humans. Nifuroxazide has also shown to be potent inhibitor of STAT signaling that shows cytotoxicity against myeloma cells that depend on STAT3 for survival . Nifuroxazide is described to block constitutive phosphorylation of STAT3 by reducing Jak kinase autophosphorylation, decreasing the viability of myeloma cells depending on constitutive STAT3 activity for survival while not affecting normal peripheral blood mononuclear cells. Nifuroxazide produces decreases in tyrosine phosphorylation of Jak2 and Tyk2, and showed no effects on EGF receptor tyrosine kinase or Src kinase, indicating a relative specificity of Nifuroxazide for Jak2 and Tyk2. Nifuroxazide shows no inhibition of Akt or MAPK phosphorylation.

REFERENCES
[1]Lambert-Zechovsky N; Dupont-Quentin E; Bingen E Clinical and bacteriological study of nifuroxazide in children (author's transl) Annales de pediatrie (1980), 27(5), 331-5.
[2] Vanhoof R, Coignau H, Stas G, Butzler JP. Evaluation of the in vitro activity of nifuroxazide on enteropathogenic microorganisms: determination of bacteriostatic and bactericidal concentrations and disk susceptibility. Acta Clin Belg. 1981;36(3):126-9.
[3] Bouree P; Chaput J C; Krainik F; Michel H; Trepo C Double-blind controlled study of the efficacy of nifuroxazide versus placebo in the treatment of acute diarrhea in adults Gastroenterologie clinique et biologique (1989), 13(5), 469-72.
[4] Chevrel B. Treatment of acute gastroenteritis of infants with nifuroxazide. Med Chir Dig. 1982;11(5):377-9.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of October 15, 2024


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CATEGORIES

 APIs and Bioactives > Antibacterials


PubChem
  @PubMed