REVIEW Nifuroxazide is an oral nitrofuran antibiotic (1966) and used worldwide to treat colitis and diarrhea in humans and non-humans. Nifuroxazide has also shown to be potent inhibitor of STAT signaling that shows cytotoxicity against myeloma cells that depend on STAT3 for survival . Nifuroxazide is described to block constitutive phosphorylation of STAT3 by reducing Jak kinase autophosphorylation, decreasing the viability of myeloma cells depending on constitutive STAT3 activity for survival while not affecting normal peripheral blood mononuclear cells. Nifuroxazide produces decreases in tyrosine phosphorylation of Jak2 and Tyk2, and showed no effects on EGF receptor tyrosine kinase or Src kinase, indicating a relative specificity of Nifuroxazide for Jak2 and Tyk2. Nifuroxazide shows no inhibition of Akt or MAPK phosphorylation.
REFERENCES
[1]
Lambert-Zechovsky N; Dupont-Quentin E; Bingen E Clinical and bacteriological study of nifuroxazide in children (author's transl) Annales de pediatrie (1980), 27(5), 331-5.
[2]
Vanhoof R, Coignau H, Stas G, Butzler JP. Evaluation of the in vitro activity of nifuroxazide on enteropathogenic microorganisms: determination of bacteriostatic and bactericidal concentrations and disk susceptibility. Acta Clin Belg. 1981;36(3):126-9.
[3]
Bouree P; Chaput J C; Krainik F; Michel H; Trepo C Double-blind controlled study of the efficacy of nifuroxazide versus placebo in the treatment of acute diarrhea in adults Gastroenterologie clinique et biologique (1989), 13(5), 469-72.
[4]
Chevrel B. Treatment of acute gastroenteritis of infants with nifuroxazide. Med Chir Dig. 1982;11(5):377-9.
All products are stocked and shipped from San Francisco Bay Area, California, USA.
⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.
These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.
Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.
New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.
Add to Favorites 
Delete from Favorites 
