REVIEW Palmatine is a protoberberine isoquinoline alkaloid found in several plants including Phellodendron amurense, Rhizoma coptidis/Coptis Chinensis and Corydalis yanhusuo. Palmatine is an example of an active component of Chinese traditional medicine. It is also the major component of the protoberberine extract from Enantia chlorantha. Palmatine has been studied for its potential use in the treatment of jaundice, dysentery, hypertension, inflammation, and liver-related diseases. The compound also has weak in vitro activity against flavivirus. Palmatine also suppressed West Nile virus without detectable and could also suppress dengue virus and yellow fever virus. Palmatine has also been shown to bind to double stranded DNA and RNA and also been used as penetrating cation conjugates for drugs against various pathologies and aging as mitochondria-targeted antioxidants and selective mild uncouplers.
REFERENCES
[1]
Yao Xue Xue Bao. Determination of berberine and palmatine in cortex phellodendron and Chinese patent medicines by HPLC. 1989;24(4):275-9.
[2]
Wang YM, Zhao LB, Lin SL, Dong SS, An DK. Virtanen P., Njimi T., Ekotto Mengata D. Clinical trials of hepatitis cure with protoberberine alkaloids of Enantia Chlorantha (abstract) Eur.J.Clin.Pharmacol.36: A123, 1989b.
[3]
Bhadra K, Kumar GS. Therapeutic potential of nucleic acid-binding isoquinoline alkaloids: binding aspects and implications for drug design. Med Res Rev. 2011 Nov;31(6):821-62.
[4]
Bhadra K, Kumar GS. Interaction of berberine, palmatine, coralyne, and sanguinarine to quadruplex DNA: a comparative spectroscopic and calorimetric study. Biochim Biophys Acta. 2011 Apr;1810(4):485-96.
All products are stocked and shipped from San Francisco Bay Area, California, USA.
⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.
These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.
Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.
New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.
Add to Favorites 
Delete from Favorites 
