2135-17-3 Flumethasone AKSci J51320
 
 
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  J51320    
Flumethasone
, 95%
 



IDENTITY
CAS Number:2135-17-3
MDL Number:MFCD00056464
MF:C22H28F2O5
MW:410.45
EINECS:218-370-9
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:265-273°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Anti-Inflammatory Agent; Glucocorticoid
Form:Free Base

REVIEW

 Flumethasone is a difluorinated glucocorticoid receptor agonist and used for the treatment of contact dermatitis, atopic dermatitis, exczema, psoriasis, diaper rash and other skin conditions. It binds to the nucleus causing a variety of genetic activation and repressions. Flumethasone is the active drug from flumethasone pivalate, a prodrug, a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties.

REFERENCES
[1]Scaglione F; Falchi M; Bichisao E; Fraschini F. Flumethasone pivalate (Locorten) in the treatment of oral diseases. Drugs under Experimental and Clinical Research. (1985) 11(8): 523-6.
[2] Bluefarb S M; Howard F M; Leibsohn E; Schlagel C A; Wexler L. Diflorasone diacetate: vasoconstrictor activity and clinical efficacy of a new topical corticosteroid. The Journal of International Medical Research (1976) 4(6): 454-61.
[3] Stahle I O. Double-blind comparisons of topically applied steroids. A critical review of methods. The British Journal of Dermatology. (1967) 79(8): 460-74.
[4] Steroids (1962), GB 903049 19620809.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H351

Precautionary Statements
P201; P202; P281; P308+P313; P405; P501


Current as of August 19, 2022


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