REVIEW Flumethasone is a difluorinated glucocorticoid receptor agonist and used for the treatment of contact dermatitis, atopic dermatitis, exczema, psoriasis, diaper rash and other skin conditions. It binds to the nucleus causing a variety of genetic activation and repressions. Flumethasone is the active drug from flumethasone pivalate, a prodrug, a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties.
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Bluefarb S M; Howard F M; Leibsohn E; Schlagel C A; Wexler L. Diflorasone diacetate: vasoconstrictor activity and clinical efficacy of a new topical corticosteroid. The Journal of International Medical Research (1976) 4(6): 454-61.
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Stahle I O. Double-blind comparisons of topically applied steroids. A critical review of methods. The British Journal of Dermatology. (1967) 79(8): 460-74.
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