113617-63-3 Orbifloxacin AKSci J50818
 
 
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  J50818    AKSci Bulk Reagent
Orbifloxacin
, 98%
 
1-Cyclopropyl-5,6,8-trifluoro-1,4-dihydro-7-(cis-3,5-dimethyl-1-piperazinyl)-4-oxo-quinoline-3-carboxylic acid




IDENTITY
CAS Number:113617-63-3
MDL Number:MFCD00864858
MF:C19H20F3N3O3
MW:395.38
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98%
Physical Form (at 20°C):Solid
Melting Point:259-265°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW

 Orbifloxacin (Orbax, Schering-Plough Animal Health) is a broad-spectrum fluoroquinolone antibiotic. Its mechanism of action is to inhibit bacterial DNA gyrase and prevent DNA supercoiling and synthesis.. The compound is approved for use in dogs for the treatment of urinary tract infections (cystitis) caused by susceptible strains of Staphylococcus pseudintermedius, Proteus mirabilis, Escherichia coli and Enterococcus faecalis. Orbifloxacin as an oral suspension is also indicated for skin and soft tissue infections in dogs caused by susceptible strains of Staphylococcus pseudintermedius, Staphylococcus aureus, coagulase positive staphylococci, Pasteurella multocida, Proteus mirabilis, Pseudomonas spp., Klebsiella pneumoniae, Escherichia coli, Enterobacter spp., Citrobacter spp., Enterococcus faecalis, β-hemolytic streptococci (Group G) and Streptococcus equisimilis.

REFERENCES
[1]Matsumoto, Junichi; Miyamoto, Teruyuki; Egawa, Hiroshi; Nakamura, Shinichi Preparation of trifluoroquinolonecarboxylic acid derivatives as medical bactericides Eur. Pat. Appl. (1987), EP 242789 A2 19871028.
[2] Petersen, Uwe; Grohe, Klaus; Schriewer, Michael; Schenke, Thomas; Haller, Ingo; Metzger, Karl; Endermann, Rainer; Zeiler, Hans Joachim Preparation of 5-substituted quinolone- and naphthyridonecarboxylic acids as antibacterial agents Ger. Offen. (1988), DE 3711193 A1 19881013.
[3] Teruyuki Miyamoto , Junichi Matsumoto , Katsumi Chiba , Hiroshi Egawa , Kohichiro Shibamori , Akira Minamida , Yoshiro Nishimura , Hidetsugu Okada , Masahiro Kataoka Pyridonecarboxylic acids as antibacterial agents. Part 14. Synthesis and structure-activity relationships of 5-substituted 6,8-difluoroquinolones, including sparfloxacin, a new quinolone antibacterial agent with improved potency.
[4] Gootz, Thomas D.; McGuirk, Paul R.; Moynihan, Melinda S.; Haskell, Suzanne L. Placement of alkyl substituents on the C-7 piperazine ring of fluoroquinolones: dramatic differential effects on mammalian topoisomerase II and DNA gyrase Antimicrobial Agents and Chemotherapy (1994), 38(1), 130-3.
[5] Nakamura S. Veterinary use of new quinolones in Japan. Drugs. 1995;49 Suppl 2:152-8.
[6] In vitro antimicrobial activity of orbifloxacin against Staphylococcus intermedius isolates from canine skin and ear infections.Gani?re JP, M?daille C, Etor? F. Res Vet Sci. 2004 Aug;77(1):67-71.
[7] Scott DW, Peters J, Miller WH JrEfficacy of orbifloxacin tablets for the treatment of superficial and deep pyoderma due to Staphylococcus intermedius infection in dogs Scott DW, Peters J, Miller WH Jr. Can Vet J. 2006 Oct;47(10):999-1002.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of October 15, 2024


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All batches backed with full quality assurance.
⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

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CATEGORIES

 APIs and Bioactives > Antibacterials, Quinolones, Veterinary


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