52-21-1 Prednisolone acetate AKSci J50191

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J50191
Prednisolone acetate, 95%

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21-Acetoxy-1,4-pregnadiene-11beta,17alpha-diol-3,20-dione

Omnipred

Prednisolone 21-acetate

Structure N/A

IDENTITY
CAS Number:	52-21-1
MDL Number:	MFCD00037710
MF:	C23H30O6
MW:	402.48
EINECS:	200-134-1
BRN:	3111798

SPECIFICATIONS & PROPERTIES
Purity:	95%
Physical Form:	White to off-white powder
Melting Point:	245-252°C
Optical Rotation:	+105 ~ +118° (c=1, Dioxane)
Long-Term Storage:	Store at room temperature
UN #:	UN2811
Hazard Class:	6.1; Poison
Packing Group:	III

BIOLOGICAL INFO
Solubility:	CHCl3:MeOH (1:1): 50mg/mL
Application(s):	Anti-Inflammatory Agent; Glucocorticoid Receptors (GR)
Form:	Free Base

REVIEW
A synthetic glucocorticoid, a derivative of cortisol, which is used to treat a variety of inflammatory and auto-immune conditions. Prednisolone irreversibly binds with glucocorticoid receptors (GR) alpha and beta for which they have a high affinity.

REFERENCES

[1]	McLean NJ, Ward DA, Hendrix DV, Vaughn RK (2012). Effects of one-week versus one-day preoperative treatment with topical 1% prednisolone acetate in dogs undergoing phacoemulsification. J Am Vet Med Assoc. 240(5):563-9. PMID 22332625.
[2]	Nien CJ, Flynn KJ, Chang M, Brown D, Jester JV (2011). Reducing peak corneal haze after photorefractive keratectomy in rabbits: prednisolone acetate 1.00% versus cyclosporine A 0.05%. J Cataract Refract Surg. 37(5):937-44. PMID 21406325.

GHS

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