52-21-1 Prednisolone acetate AKSci J50191
 
 
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  J50191    
Prednisolone acetate, 95%
 
21-Acetoxy-1,4-pregnadiene-11beta,17alpha-diol-3,20-dione
Omnipred
Prednisolone 21-acetate
IDENTITY
CAS Number:52-21-1
MDL Number:MFCD00037710
MF:C23H30O6
MW:402.48
EINECS:200-134-1
BRN:3111798
SPECIFICATIONS & PROPERTIES
Purity:95%
Physical Form:White to off-white powder
Melting Point:245-252°C
Optical Rotation:+105 ~ +118° (c=1, Dioxane)
Long-Term Storage:Store at room temperature
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III

BIOLOGICAL INFO
Solubility:CHCl3:MeOH (1:1): 50mg/mL
Application(s):Anti-Inflammatory Agent; Glucocorticoid Receptors (GR)
Form:Free Base

REVIEW
 A synthetic glucocorticoid, a derivative of cortisol, which is used to treat a variety of inflammatory and auto-immune conditions. Prednisolone irreversibly binds with glucocorticoid receptors (GR) alpha and beta for which they have a high affinity.

REFERENCES
[1]McLean NJ, Ward DA, Hendrix DV, Vaughn RK (2012). Effects of one-week versus one-day preoperative treatment with topical 1% prednisolone acetate in dogs undergoing phacoemulsification. J Am Vet Med Assoc. 240(5):563-9. PMID 22332625.
[2] Nien CJ, Flynn KJ, Chang M, Brown D, Jester JV (2011). Reducing peak corneal haze after photorefractive keratectomy in rabbits: prednisolone acetate 1.00% versus cyclosporine A 0.05%. J Cataract Refract Surg. 37(5):937-44. PMID 21406325.

GHS

Pictograms

Signal Word
Danger

Hazard Statements
H300

Precautionary Statements
P264; P270; P301+P310; P321; P330; P405; P501

Current as of July 13, 2020


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CATEGORIES
 APIs and Bioactives > Immunomodulators


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