94-24-6 Tetracaine AKSci J50010
 
 
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  J50010    AKSci Bulk Reagent
Tetracaine, 95%
 
4-(Butylamino)benzoic acid 2-(Dimethylamino)ethyl ester
-(Dimethylamino)ethyl 4-(butylamino)benzoate
IDENTITY
CAS Number:94-24-6
MDL Number:MFCD00053787
MF:C15H24N2O2
MW:264.36
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:41-46°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III
A hazmat fee may apply to certain package sizes and shipment methods. Please check pricing table for an indicator of applicable hazmat fees.

REVIEW
 Tetracaine also known as amethocaine (trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia. It can be applied as a cream or as a patcvh, plaster or peel. In regard to its mode of action, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.

REFERENCES
[1]WIEDLING S; TEGNER C LOCAL ANESTHETICS Progress in medicinal chemistry (1963), 19, 332-98.
[2] Covino B G Comparative clinical pharmacology of local anesthetic agents Anesthesiology (1971), 35(2), 158-67.
[3] Webb, Alistair I.; Pablo, Luisito S. Edited by Riviere, Jim Edmond; Papich, Mark G Local Anesthetics Veterinary Pharmacology and Therapeutics (9th Edition) (2009), 381-399.
[4] Kaur, Sharonjeet; Kaushal, Sandeep; Chopra, Sarvesh Chander Lidocaine/tetracaine peel Journal of Anaesthesiology, Clinical Pharmacology (2007), 23(3), 279-282.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H301; H317; H351

Precautionary Statements
P201; P202; P261; P264; P270; P272; P280; P301+P310; P302+P352; P308+P313; P321; P330; P333+P313; P363; P405; P501

RELATED PRODUCTS
K715Tetracaine
H770Tetracaine HCl

Current as of November 21, 2024


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CATEGORIES
 APIs and Bioactives > Anaesthetics


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