763113-22-0 Olaparib AKSci J20655
 
 
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  J20655    
Olaparib, 98% (HPLC)
 



IDENTITY
CAS Number:763113-22-0
MDL Number:MFCD13185161
MF:C24H23FN4O3
MW:434.46
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO =85mg/mL, Water <1.2mg/mL, Ethanol =5.5mg/mL
Application(s):Selective inhibitor of PARP1 and PARP2
Form:Free base

REVIEW
 Olaparib is a small molecule inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing, and antineoplastic activities. It selectively binds to and inhibits PARP. The inhibition may enhance the cytotoxicity of DNA-damaging agents and may reverse tumor cell chemoresistance and radioresistance. It acts against cancers in people with hereditary BRCA1 or BRCA2 mutations, which includes many ovarian, breast and prostate cancers.

REFERENCES
[1]Vasiliou, S.; Castaner, R.; Bolos, J. Olaparib: PARP-1 and PARP-2 inhibitor oncolytic. Drugs of the Future. (2009) 34(2): 101-105.
[2] Chen, Ying; Zhang, Lei; Hao, Quan. Olaparib: a promising PARP inhibitor in ovarian cancer therapy. Archives of Gynecology and Obstetrics. (2013) 288(2): 367-374.
[3] Menear, Keith A.; Adcock, Claire; Boulter, Robert; Cockcroft, Xiao-ling; Copsey, Louise; Cranston, Aaron; Dillon, Krystyna J.; Drzewiecki, Jan; Garman, Sheila; Gomez, Sylvie; et al. 4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: A Novel Bioavailable Inhibitor of Poly(ADP-ribose) Polymerase-1. Journal of Medicinal Chemistry. (2008) 51(20): 6581-6591
[4] Martin, Niall Morrison Barr; Smith, Graeme Cameron Murray; Jackson, Stephen Philip; Loh, Vincent M., Jr.; Cockcroft, Xiao-Ling Fan; Matthews, Ian Timothy Williams; Menear, Keith Allan; Kerrigan, Frank; Ashworth, AlanPreparation of phthalazinones as PARP inhibitors PCT Int. Appl. (2004), WO 2004080976 A1 20040923.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H301; H360; H372

Precautionary Statements
P264; P201; P202; P281; P260; P301+P310; P330; P308+P313; P314

Current as of April 19, 2024


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