REVIEW Orlistat is a drug designed to treat obesity. Orlistat works by inhibiting gastric and pancreatic lipases, the enzymes that break down triglycerides in the intestine. When lipase activity is blocked, triglycerides from the diet are not hydrolyzed into absorbable free fatty acids, and are excreted undigested instead.
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Gelebart P, Zak Z, Anand M, Belch A, Lai R (2012). Blockade of fatty acid synthase triggers significant apoptosis in mantle cell lymphoma. PLoS One. 7(4):e33738. PMID 22485149.
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