REVIEW Tetrandrine a bis-benzylisoquinoline alkaloid, a principle from a traditional Chinese medicine of the root of Stephania tetrandra S Moore, and other Chinese and Japanese herbs,and is a calcium channel blocker with a wide range of biological effects. Tetrandrine demonstrates antiinflammatory, antifibrogenetic, immunomodulating and antioxidant effects, it also presents antiallergic effects, inhibitory effects on pulmonary vessels and airway smooth muscle contraction, and platelet aggregation via its nonspecific calcium channel antagonism that suggested its potential in the treatment of asthma, pulmonary hypertension and chronic obstructive pulmonary disease.
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