88150-47-4 Amlodipine maleate AKSci J11722
 
 
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  J11722    
Amlodipine maleate
, >98% (HPLC)
 



IDENTITY
CAS Number:88150-47-4
MDL Number:MFCD02259457
MF:C20H25ClN2O5.C4H4O4
MW:524.95
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:175-179°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Calcium channel blocker

REVIEW

 Amlodipine benzenesulfonate is a long-acting dihydropyridine calcium channel blocker used as an antihypertensive and in the treatment of angina pectoris. It acts by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance and thereby reducing blood pressure. In angina, amlodipine increases blood flow to the heart muscle.

REFERENCES
[1]Arrowsmith, John E.; Campbell, Simon F.; Cross, Peter E.; Stubbs, John K.; Burges, Roger A.; Gardiner, Donald G.; Blackburn, Kenneth J. Long-acting dihydropyridine calcium antagonists. 1. 2-Alkoxymethyl derivatives incorporating basic substituents Journal of Medicinal Chemistry (1986), 29(9), 1696-702.
[2] Coppi, Laura; Gasanz, Guillen Yolanda; Campon, Pardo Julio Intermediate for the synthesis of amlodipine, preparation process and corresponding utilization PCT Int. Appl. (2000), WO 2000024714 A1 20000504.
[3] Peters, Theodorus H. A.; Benneker, Franciscus B. G.; Slanina, Pavel; Bartl, Jiri Process for making amlodipine and related compounds via cyclocondensation of 2-(o-chlorobenzylidene)-4-(2-phthalimidoethoxy)acetoacetates with 3-aminocrotonates U.S. Pat. Appl. Publ. (2002), US 20020143046 A1 20021003.
[4] Nayler WG, Gu XH: The unique binding properties of amlodipine: a long-acting calcium antagonist. J Hum Hypertens. 1991 Aug;5 Suppl 1:55-9.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of September 29, 2022


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CATEGORIES

 APIs and Bioactives > Calcium Channel Blockers


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