104146-10-3 Cephalosporin Impurity 4 AKSci J11649
 
 
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  J11649    
Cephalosporin Impurity 4, 98% (N)
 
4-Methoxybenzyl 3-Chloromethyl-7-(2-phenylacetamido)-3-cephem-4-carboxylate
IDENTITY
CAS Number:104146-10-3
MDL Number:MFCD00191253
MF:C24H23ClN2O5S
MW:486.97
BRN:4894110
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (N)
Physical Form (at 20°C):Solid
Melting Point:163-169°C
Optical Rotation:-44° (c=1%, CDCl3)
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW
 An advanced cephalosporin beta-lactam intermediate used in the preparation of antibiotics.

REFERENCES
[1]Yamauchi, Hiroshi; Sugiyama, Isao; Saito, Isao; Nomoto, Seiichiro; Kamiya, Takashi; Machida, Yoshimasa; Negi, Shigeto Cephem derivatives Eur. Pat. Appl. (1986), EP 188255 A2 19860723.
[2] Nishide, Kiyoharu; Yamamura, Mariko; Kobori, Takeo; Tunemoto, Daiei; Kondo, Kiyosi; Sato, Kiyoshi A synthesis of new 3-dialkoxyphosphinylmethyl and 3-dihydroxyphosphinylmethyl cephalosporins Chemical & Pharmaceutical Bulletin (1988), 36(7), 2354-61.
[3] Farina, Vittorio; Baker, Stephen R.; Benigni, Daniel A.; Hauck, Sheila I.; Sapino, Chester, Jr. Palladium catalysis in cephalosporin chemistry: general methodology for the synthesis of cephem side chains Journal of Organic Chemistry (1990), 55(23), 5833-47.
[4] Sakagami, Kenji; Atsumi, Kunio; Tamura, Atsushi; Yoshida, Takashi; Nishihata, Ken; Fukatsu, Shunzo Synthesis and oral activity of ME 1207, a new orally active cephalosporin Journal of Antibiotics (1990), 43(8), 1047-50.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 19, 2024


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CATEGORIES
 APIs and Bioactives > Cephalosporins


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