25316-40-9 Doxorubicin HCl AKSci J11620
 
 
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  J11620    
Doxorubicin HCl, >98% (HPLC)
 
Doxorubicin
DOX, Hydroxydaunorubicin hydrochloride
Adriamycin
more..
IDENTITY
CAS Number:25316-40-9
MDL Number:MFCD00077757
MF:C27H29NO11.HCl
MW:579.98
EINECS:246-818-3
BRN:4229251
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:210-220°C
Optical Rotation:+240° to +270° (c=0.1, MeOH)
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Inhibits DNA topoisomerase II and induces DNA damage and apoptosis
Form:HCl salt
Research Area:Inhibitor of reverse transcriptase and RNA polymerase; immunosuppressive agent; intercalates in DNA.

REVIEW
 A broad spectrum antitumor agent. Induces DNA damage by intercalating into DNA and inhibiting topoisomerase II. Binds covalently to DNA. Inhbibits reverse transcriptase, RNA polymerase and the catalytic activity of Dnmt1. Immunosuppressive. Antineoplastic. Induces apoptosis. Down regulates c-myc and c-jun in doxorubicin-sensitive cells.

REFERENCES
[1]K.B. Wallace. Adriamycin-induced interference with cardiac mitochondrial calcium homeostasis. Cardiovasc. Toxicol. 7, 101 (2007)
[2] Laginha, K.M. Determination of Doxorubicin Levels in Whole Tumor and Tumor Nuclei in Murine Breast Cancer Tumors. Clinical Cancer Research. October 1, 2005. Vol. 11 (19). Retrieved on April 19, 2007.
[3] Gamo F-J et al. (2010). Thousands of chemical starting points for antimalarial lead identification. Nature 465 (7296): 305-310. PMID 20485427.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H302; H315; H319; H350

Precautionary Statements
P201; P202; P264; P270; P280; P301+P312; P302+P352; P305+P351+P338; P308+P313; P321; P330; P332+P313; P337+P313; P362; P405; P501

Current as of April 25, 2024


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All products are stocked and shipped from San Francisco Bay Area, California, USA.

⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.
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WARNING: Attention California residents: This product can expose you to chemicals including Doxorubicin HCl, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.




CATEGORIES
 APIs and Bioactives > Chemotherapeutics


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