50-35-1 (+/-)-Thalidomide AKSci J11581
 
 
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  J11581    AKSci Reference Standard
(+/-)-Thalidomide, 99% (HPLC), powder
 
Thalomid
(+/-)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
IDENTITY
CAS Number:50-35-1
MDL Number:MFCD00153873
MF:C13H10N2O4
MW:258.23
EINECS:200-031-1
SPECIFICATIONS & PROPERTIES
Purity:99% (HPLC), powder
Spectra:NMR, LCMS, FT-IR, HPLC
Physical Form:White to off-white crystalline powder
Melting Point:269-276°C
Long-Term Storage:Store at room temperature
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III

BIOLOGICAL INFO
Application(s):Angiogenesis Inhibitor; Immunosuppressive Agent; Leprostatic Agent; Teratogen
Form:Free Base

REVIEW
 Thalidomide is used for treating multiple myeloma in combination with dexamethasone, erythema nodosum leprosum, and alleviating symptoms of HIV, with strict controls to prevent birth defects. Thalidomide is a potent inhibitor of new blood vessel growth (angiogenesis), which is required for tumor growth.

REFERENCES
[1]Bejanyan N, Tiu RV, Raza A, Jankowska A, Kalaycio M, Advani A, Chan J, Saunthararajah Y, Mooney L, Maciejewski JP, Sekeres MA (2012). A phase 2 trial of combination therapy with thalidomide, arsenic trioxide, dexamethasone, and ascorbic acid (TADA) in patients with overlap myelodysplastic/myeloproliferative neoplasms (MDS/MPN) or primary myelofibrosis (PMF). Cancer. 118(16):3968-76. PMID 22180010.
[2] Horton MR, Hallowell RW (2012). Revisiting thalidomide: fighting with caution against idiopathic pulmonary fibrosis. Drugs Today (Barc). 48(10):661-71. PMID 23110262.

GHS

Pictograms

Signal Word
Danger

Hazard Statements
H301; H312; H361

Precautionary Statements
P201; P202; P264; P270; P280; P301+P310; P302+P352; P308+P313; P322; P330; P363; P405; P501

Current as of July 12, 2020

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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For research use only. Not for diagnostic or therapeutic use. Not for human use. AK Scientific, Inc. does not sell to individuals. If you are a first-time customer, please email for review at least two official business documents issued by your local jurisdiction, state/province, or country.

WARNING: Attention California residents: This product can expose you to chemicals including (+/-)-Thalidomide, which is known to the State of California to cause birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov.


CATEGORIES
 APIs and Bioactives > Immunomodulators


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