6223-35-4 Sodium gualenate AKSci J11506
 
 
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  J11506    AKSci Reference Standard
Sodium gualenate, >98% (HPLC)
 
Azupromin
Azulen SN
Sodium guiazulene sulfonate, Sodium 7-Isopropyl-1,4-dimethylazulene-3-sulfonate
IDENTITY
CAS Number:6223-35-4
MDL Number:MFCD00866167
MF:C15H17NaO3S
MW:300.35
EINECS:228-309-8
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC)
Physical Form (at 20°C):Solid
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Anti-inflammatory; Antiulcerative
Form:Sodium salt

REVIEW
 Sodium gualenat is a water-soluble derivative of azulene, a natural product which is an antiinflammatory component of chamomile of the family of Asteraceae. Sodium gualenate was originally studied as an antiulcer agent, but it is also clinically used as a therapeutic agent in the treatment of inflammation of the mouth and throat, for example, pharyngitis as well as other inflammatory diseases such as tonsillitis, stomatitis and conjunctivitis.

REFERENCES
[1]Nakamichi K, Nakano T, Yasuura H, Izumi S, Kawashima Y (2003). Stabilization of sodium guaiazulene sulfonate in granules for tableting prepared using a twin-screw extruder. Eur J Pharm Biopharm. 56(3):347-54. PMID 14602176.
[2] Ogata J, Minami K, Horishita T, Shiraishi M, Okamoto T, Terada T, Sata T (2005). Gargling with sodium azulene sulfonate reduces the postoperative sore throat after intubation of the trachea. Anesth Analg. 101(1):290-3, table of contents. PMID 15976248.
[3] Thiemer, K.; Stadler, R.; Isaac, O; Biochemical studies on chamomile constituents. 1. Antipeptic activity of chamomile extract and sodium 1,4-dimethyl-7-isopropylazulenesulfonate. Arzneimittel-Forschung (1972), 22(6), 1086-7.
[4] Yanagisawa, Takashi; Kosakai, Kazuhiro; Tomiyama, Tsuyoshi; Yasunami, Masafumi; Takase, Kahei; Studies on antiulcer agents. II. Synthesis and antiulcer activities of 6-isopropylazulene-1-sodium sulfonate derivatives Chemical & Pharmaceutical Bulletin (1990), 38(12), 3355-8.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of September 19, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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