69657-51-8 Acyclovir sodium AKSci J11471
 
 
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  J11471    AKSci Reference Standard
Acyclovir sodium
, 99% (HPLC), powder
 



IDENTITY
CAS Number:69657-51-8
MDL Number:MFCD01694138
MF:C8H10N5O3.Na
MW:247.19
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Physical Form (at 20°C):White powder
Melting Point:269-272°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW

 Viral (HSV-1, HSV-2 and VZV) thymidine kinase converts aciclovir to the aciclovir monophosphate, which is then converted to the diphosphate by cellular guanylate kinase, and finally to the triphosphate by phosphoglycerate kinase, phosphoenolpyruvate carboxykinase, and pyruvate kinase. Aciclovir triphosphate competitively inhibits viral DNA polymerase and competes with the natural deoxyguanosine triphosphate, for incorporation into viral DNA. Once incorporated, aciclovir triphosphate inhibits DNA synthesis by acting as a chain terminator.

REFERENCES
[1]O'Brien JJ, Campoli-Richards DM: Acyclovir. An updated review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy. Drugs. 1989 Mar;37(3):233-309.
[2] de Clercq, Erik; Field, Hugh J (5 October 2005). Antiviral prodrugs - the development of successful prodrug strategies for antiviral chemotherapy. British Journal of Pharmacology 147 (1) (Wiley-Blackwell January 2006). pp. 1-11. doi:10.1038/sj.bjp.0706446. PMC 1615839. PMID 16284630
[3] Schaffer, Howard; Robert Vince, S. Bittner, S. Gurwara (1971). Novel substrate of adenosine deaminase. Journal of Medicinal Chemistry 14 (4): 367-369. doi:10.1021/jm00286a024. PMID 5553754.
[4] Elion, Gertrude; Furman, Fyfe, Miranda, Beauchamp and Schaffer (1977). Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine. Proc Natl Acad Sci USA 74 (12): 5716-5720. doi:10.1073/pnas.74.12.5716. PMC 431864. PMID 202961.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of May 22, 2022

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Antivirals


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