105628-07-7 Fasudil hydrochloride AKSci J11462
 
 
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  J11462    
Fasudil hydrochloride, >98% (HPLC), powder
 
Fasudil
5-(1-Homopiperazinyl)sulfonylisoquinoline hydrochloride
1-(5-Isoquinolinesulfonyl)homopiperazine hydrochloride
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IDENTITY
CAS Number:105628-07-7
MDL Number:MFCD00943198
MF:C14H18ClN3O2S
MW:327.83
BRN:5466340
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:208-215°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:Soluble in water and methanol; Very slightly soluble in ethanol; Insoluble in ether
Application(s):Rho-kinase inhibitor and vasodilator

REVIEW
 RhoA/Rho kinase(ROCK) inhibitor that plays an important role in mediating vasoconstriction and vascular remodeling in the pathogenesis of PH. ROCK induces vasoconstriction by phosphorylating the myosin-binding subunit of myosin light chain (MLC) phosphatase, thus decreasing MLC phosphatase activity and enhancing vascular smooth muscle contraction.

REFERENCES
[1]Nagumo, H., Sasaki, Y., Ono, Y., Okamato, H., Seto, M., and Takuwa, Y. (2000). Rho kinase inhibitor HA-1077 prevents Rho-mediated myosin phosphatase inhibition in smooth muscle cells. American Journal of Physiology. 278: C57-C65.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of March 26, 2023


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CATEGORIES
 APIs and Bioactives > Protein Kinase Inhibitors


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