191732-72-6 Lenalidomide AKSci J11411
 
 
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  J11411    AKSci Reference Standard
Lenalidomide, >98% (HPLC), powder
 
Revlimid
Revimid
3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione
IDENTITY
CAS Number:191732-72-6
MDL Number:MFCD07772307
MF:C13H13N3O3
MW:259.26
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:256-266°C
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Antineoplastic Agent; TNF-a secretion inhibitor
Form:Free Base

REVIEW
 Lenalidomide has been used to successfully treat both inflammatory disorders and cancers. There are multiple mechanisms of action, and they can be simplified by organizing them as mechanisms of action in vitro and in vivo. In vitro, lenalidomide has three main activities: direct anti-tumor effect, inhibition of the microenvironment support for tumor cells, and immunomodulatory role. In vivo, lenalidomide induces tumor cell apoptosis directly and indirectly by inhibition of bone marrow stromal cell support, by anti-angiogenic and anti-osteoclastogenic effects, and by immunomodulatory activity. Lenalidomide has a broad range of activities that can be exploited to treat many hematologic and solid cancers.

REFERENCES
[1]McCarthy; Philip L. McCarthy, Kouros Owzar, Craig C. Hofmeister, et al. (2012). Lenalidomide after Stem-Cell Transplantation for Multiple Myeloma. N Engl J Med 366 (19): 1770-1781. PMID 22571201
[2] Badros, Ashraf Z. Badros (2012). Lenalidomide in Myeloma - A High-Maintenance Friend. N Engl J Med 366 (19): 1836-1838. PMID 22571206.
[3] Vallet S, Palumbo A, Raje N, Boccadoro M, Anderson KC (2008). Thalidomide and lenalidomide: Mechanism-based potential drug combinations. Leukemia & Lymphoma 49 (7): 1238-45. PMID 18452080.
[4] Armoiry X, Aulagner G, Facon T (2008). Lenalidomide in the treatment of multiple myeloma: a review. Journal of Clinical Pharmacy and Therapeutics 33 (3): 219-26. PMID 18452408.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 25, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Chemotherapeutics


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