38083-17-9 Climbazole AKSci J11338
 
 
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  J11338    
Climbazole, 99% (GC)
 
1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethyl-2-butanone
IDENTITY
CAS Number:38083-17-9
MDL Number:MFCD00055505
MF:C15H17ClN2O2
MW:292.76
EINECS:253-775-4
BRN:618020
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (GC)
Physical Form (at 20°C):Solid
Melting Point:96-100°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW
 Climbazole is a topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandruff and eczema. Climbazole has shown a high in vitro and in vivo efficacy against Pityrosporum ovale that appears to play an important role in the pathogenesis of dandruff. Its chemical structure and properties are similar to other fungicides such as ketoconazole and miconazole. It is most commonly found as an active ingredient in over the counter anti-dandruff and anti-fungal products, including shampoos, lotions and conditioners. It may be accompanied by other active ingredients such as zinc pyrithione or triclosan.

REFERENCES
[1]Meiser, Werner; Buechel, Karl Heinz; Plempel, Manfred Antimycotic imidazole derivatives Ger. Offen. (1972), DE 2105490 A 19720810.
[2] Meiser, Werner; Buechel, Karl H.; Kraemer, Wolfgang; Grewe, Ferdinand; Frohberger, Paul E Fungicidal imidazolylmethyl ketones Ger. Offen. (1974), DE 2325156 A1 19741205.
[3] Buechel, Karl H.; Plempel, Manfred Azole antimycotics as cosmetic agents Ger. Offen. (1976), DE 2430039 A1 19760108.
[4] Wigger-Alberti W, Kluge K, Elsner P.Clinical effectiveness and tolerance of climbazole containing dandruff shampoo in patients with seborrheic scalp eczema. Praxis (Bern 1994). 2001 Aug 16;90(33):1346-9.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302; H410

Precautionary Statements
P264; P270; P273; P301+P312+P330; P391; P501

Current as of April 20, 2024


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⚠️
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CATEGORIES
 APIs and Bioactives > Fungicides


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