34580-14-8 Ketotifen fumarate AKSci J11276
 
 
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  J11276    AKSci Reference Standard
Ketotifen fumarate
, 98% (HPLC)
 
Ketotifen fumarate salt
Ketotifen hydrogen fumarate




IDENTITY
CAS Number:34580-14-8
MDL Number:MFCD00079394
MF:C23H23NO5S
MW:425.5
EINECS:252-100-0
BRN:4089486
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form:White to off-white to pale yellow powder
Melting Point:192-200°C
Long-Term Storage:Store at room temperature
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:MeOH: 50mg/mL
Application(s):H1-antihistamine and mast cell stabilizer
Form:Fumaric acid salt

REVIEW

 Ketotifen is a relatively selective, non-competitive histamine antagonist (H1-receptor) and mast cell stabilizer. Ketotifen inhibits the release of mediators from mast cells involved in hypersensitivity reactions. Decreased chemotaxis and activation of eosinophils have also been demonstrated. Ketotifen also inhibits cAMP phosphodiesterase. Properties of ketotifen which may contribute to its antiallergic activity and its ability to affect the underlying pathology of asthma include inhibition of the development of airway hyper-reactivity associated with activation of platelets by PAF (Platelet Activating Factor), inhibition of PAF-induced accumulation of eosinophils and platelets in the airways, suppression of the priming of eosinophils by human recombinant cytokines and antagonism of bronchoconstriction due to leukotrienes. Ketotifen inhibits of the release of allergic mediators such as histamine, leukotrienes C4 and D4(SRS-A) and PAF.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501


Current as of December 1, 2021

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Antihistamines


PubChem