155141-29-0 Rosiglitazone maleate AKSci J11270
 
 
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  J11270    AKSci Reference Standard
Rosiglitazone maleate, 99% (HPLC)
 
Avandia
Avandaryl
IDENTITY
CAS Number:155141-29-0
MDL Number:MFCD03427306
MF:C22H23N3O7S
MW:473.5
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:121-124°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 95mg/mL; H2O: <1mg/mL; EtOH: 2mg/mL
Application(s):Hypoglycemic Agent; Peroxisome proliferator-activated receptor (PPAR) agonist
Form:Maleate

REVIEW
 An antidiabetic drug in the thiazolidinedione class of drugs. It works as an insulin sensitizer, by binding to the PPAR receptors in fat cells and making the cells more responsive to insulin.

REFERENCES
[1]Williams CR, Lu X, Sutliff RL, Hart CM (2012). Rosiglitazone attenuates NF-κB-mediated Nox4 upregulation in hyperglycemia-activated endothelial cells. Am J Physiol Cell Physiol. 303(2):C213-23. PMID 22572850.
[2] Wu X, Li L (2012). Rosiglitazone suppresses lipopolysaccharide-induced matrix metalloproteinase-2 activity in rat aortic endothelial cells via Ras-MEK1/2 signaling. Int J Cardiol. 158(1):54-8. PMID 21247645.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

RELATED PRODUCTS
F325Rosiglitazone
H694Rosiglitazone maleate
S504Rosiglitazone hydrochloride

Current as of November 21, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Diabetes


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